Kernel Metadata Declaration — on demand
ISO 26324 asks a DOI Registration Agency to produce a Kernel Metadata Declaration for every DOI it issues. Give any DOI: its public record becomes a record in the Smart Scholars DOI Metadata Format 1.0, checked against every rule, and declared as the Kernel XML.
✓ Meets every rule of the format
The record below is complete and every controlled value is a DOI Attribute Value Set 2.3 spelling. The Declaration on the right follows DOIMetadataKernel.xsd element by element.
What the DOI identifies
Therapeutic Failures in Adult Patients Treated with Artemether-Lumefantrine: A Dual-Sector Analytical Study
10.46243/jst.2025.v10.i08.pp60-65 · JournalArticle — an article in a journal · Digital · Visual · Language · en
Published 2025-08-02
Part of Journal of Science & Technology · ISSN 2456-5660 · vol. 10 · no. 08 · pp. 60–66
Principal agents
- M.Kishore Babu (author → Author)
- B.Sandhya Rani (author → Author)
- I. Triveni (author → Author)
- B.Revathi (author → Author)
- Longman Publishers (publisher → Publisher)
Also in the record, outside the Kernel: the abstract, the licence, 4 links, 7 references. Source: Crossref (member 25296), registered 2026-08-27, last deposited 2026-09-20.
System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1
Each element by the standard's name and the Handbook's (in grey), read off the record.
| DOI Name DOI name | 10.46243/jst.2025.v10.i08.pp60-65 |
| Referent Type referentType | Creation |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal |
| Referent Name(s) referentName(s) | Therapeutic Failures in Adult Patients Treated with Artemether-Lumefantrine: A Dual-Sector Analytical Study (PrincipalTitle, en) |
| Basic Metadata basicMetadata | author: M.Kishore Babu author: B.Sandhya Rani author: I. Triveni author: B.Revathi publisher: Longman Publishers published: 2025-08-02 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 10 · no. 08 · pp. 60–66 language: en form: Digital · Visual · Language |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy |
| Created Date issueDate | 2026-08-27 |
| relatedIdentifiers | none needed — the descriptive metadata is in this record |
The record
{
"format": "smartscholars-doi-metadata/1.0",
"doi": "10.46243/jst.2025.v10.i08.pp60-65",
"referent": "Creation",
"type": "JournalArticle",
"structural_type": "Digital",
"modes": [
"Visual"
],
"characters": [
"Language"
],
"titles": [
{
"value": "Therapeutic Failures in Adult Patients Treated with Artemether-Lumefantrine: A Dual-Sector Analytical Study",
"type": "PrincipalTitle",
"lang": "en"
}
],
"identifiers": [
{
"type": "DOI",
"value": "10.46243/jst.2025.v10.i08.pp60-65"
}
],
"agents": [
{
"role": "author",
"name": {
"given": "",
"family": "M.Kishore Babu"
},
"sequence": "first"
},
{
"role": "author",
"name": {
"given": "",
"family": "B.Sandhya Rani"
},
"sequence": "additional"
},
{
"role": "author",
"name": {
"given": "",
"family": "I. Triveni"
},
"sequence": "additional"
},
{
"role": "author",
"name": {
"given": "",
"family": "B.Revathi"
},
"sequence": "additional"
},
{
"role": "publisher",
"name": {
"org": "Longman Publishers"
}
}
],
"dates": {
"published": "2025-08-02",
"date_type": "PublicationDate",
"online": "2025-08-02"
},
"language": "en",
"container": {
"type": "Journal",
"titles": [
{
"value": "Journal of Science & Technology",
"type": "PrincipalTitle"
}
],
"identifiers": [
{
"type": "ISSN",
"value": "2456-5660",
"medium": "electronic"
}
],
"volume": "10",
"issue": "08",
"pages": {
"first": "60",
"last": "66"
}
},
"links": [
{
"url": "https://www.jst.org.in/index.php/pub/article/view/1475",
"return_type": "text/html",
"primary": true
},
{
"url": "https://www.jst.org.in/index.php/pub/article/download/1475/1121",
"purpose": "text-mining",
"return_type": "application/pdf"
},
{
"url": "https://www.jst.org.in/index.php/pub/article/download/1475/1205",
"purpose": "text-mining",
"return_type": "application/xml"
},
{
"url": "https://jst.org.in/index.php/pub/article/view/1475/1121",
"purpose": "similarity-checking"
}
],
"abstract": {
"value": "Artemether-Lumefantrine medication is becoming less effective in treating simple cases of malaria in many places where the disease is prevalent. Worldwide, plasmodium falciparum and plasmodium vivax parasite tolerance, recrudescence, and resistance are on the rise. Our objective was to assess the rate of Artemether-Lumefantrine (Coartem) treatment failure in persons presenting with uncomplicated malaria at health facilities. From April 1, 2022, to June 30, 2022, 166 patients with positive malaria test results attended health facilities as part of this descriptive cross-sectional research. A total of 9.6% of malaria patients did not show improvement after receiving corticosteroids; 6.0% had plasmodium falciparum, 2.4% plasmodium vivax, and 1.2 had a mixed infection. Among those who did not take the medication with the fatty meal, 31% tested positive for malaria after two weeks of receiving coartem. Additionally, 25% of those who did not follow the treatmentschedule had not eradicated the parasite, even thoughthey received coartem. Nearly a third of patients were given Coartem without going through malaria testing, according to the data. In adults in Khartoum state, Sudan, the effectiveness of Artemether-Lumefantrine for treating uncomplicated malaria is declining. To determine how often treatments fail and what variables contribute to drugs having less of an effect, prospective trials are required. Pharmacists should not provide antimalarial medication without a doctor's order and a positive blood test for malaria.",
"lang": "en"
},
"license": {
"url": "https://creativecommons.org/licenses/by/4.0/",
"start": "2025-08-02",
"applies_to": "vor"
},
"references": [
{
"key": "ref1",
"unstructured": "Malaria. 2020. World Health Organization (WHO). 14. The United Nations World Health Organization (WHO) website provides information about malaria. Malaria Indicator Survey i n Sudan in 2018. 2018 on behalf of the Federal Ministry of Health in Khartoum, Sudan & CNCDCD. This report may be seen at: https://web archive.lshtm.ac.uk/www.linkmalaria.org/sites/link/files/content/coun try/profiles/Sudan%20PR%20risk%20map%20Final%20Report--- 2018.pdf"
},
{
"key": "ref2",
"doi": "10.1172/jci21682",
"unstructured": "White NJ. Drug resistance in malaria. Volume 113, Issue 8, Pages 1084–1092, Journal of Clinical Investigation, 2004. doi:10.1172/JCI21682"
},
{
"key": "ref3",
"unstructured": "The country's health ministry. Malaria treatment regimen for the country in 2017. The publica tion, \"Sudan: Malaria Diagnosis and Treatment Protocol 2017,\" is accessible at: https://reliefweb.int/report/sudan/sudan-19"
},
{
"key": "ref4",
"doi": "10.1186/1475-2875-11-280",
"unstructured": "John GK, Douglas NM, von Seidlein L, Nosten F, Baird JK, White NJ, and others published a study. An analysis of the literature on primaquine radical treatment for Plasmodium vivax. Published in 2012, the article may be accessed online at doi:10.1186/1475-2875-11-280"
},
{
"key": "ref5",
"doi": "10.1371/journal.pone.0154618",
"unstructured": "The authors of the article are Nega, Assefa, Mohamed, Solomon, Woyessa, Assefa Y, and Assefa A. In Metehara, Eastern Ethiopia, a regulatory clinical trial examined the therapeutic effectiveness of artemether lumefantrine (Coartem®) in treating uncomplicated P. falciparum malaria. \"Plos One\" published in 2016 with the DOI 10.1371/jou rnal.pone.0154618"
},
{
"key": "ref6",
"doi": "10.1186/s41182-018-0096-7",
"unstructured": "Authors: Rakotonandrasana DH, Tsukahara T, Yamamoto-Mitani N. A qualitative research in Madagascar on Page | 66 healthcare personnel' prescription antimalarial drugs when malaria testing comes out negative. Public Health in Tropical Regions. 2018;46:1-9. doi:10.1186/s41182-018-0096-7"
},
{
"key": "ref7",
"doi": "10.1186/1475-2875-8-s1-s4",
"unstructured": "Citation: Djimdé A, Lefèvre G. Understanding the pharmacokinetics of Coartem®. The article \"Malar J.\" was published in 2009 and can be found online at doi:10.1186/1475-2875-8-S1-S4"
}
],
"record": {
"registrant": "Longman Publishers",
"registered": "2026-08-27",
"updated": "2026-09-20",
"issue_number": 1,
"source": "crossref-api",
"source_agency": "Crossref (member 25296)"
}
}The Kernel Metadata Declaration
DOIMetadataKernel.xsd · namespace http://www.doi.org/2010/DOISchema · Attribute Value Sets 2.3 · draft — the agency's DOI name is filled in on accreditation
<?xml version="1.0" encoding="UTF-8"?>
<!-- DRAFT declaration: Smart Scholars is not yet a DOI Registration Agency. registrationAgencyDoiName is a marker (10.0/ is no RA's prefix) and is filled in on accreditation. -->
<kernelMetadata xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.doi.org/2010/DOISchema https://www.doi.org/doi_schemas/DOIMetadataKernel.xsd" xmlns="http://www.doi.org/2010/DOISchema">
<referentDoiName>10.46243/jst.2025.v10.i08.pp60-65</referentDoiName>
<primaryReferentType>Creation</primaryReferentType>
<registrationAgencyDoiName>10.0/smart-scholars-draft</registrationAgencyDoiName>
<issueDate>2026-10-04</issueDate>
<issueNumber>1</issueNumber>
<referentCreation>
<name primaryLanguage="en">
<value>Therapeutic Failures in Adult Patients Treated with Artemether-Lumefantrine: A Dual-Sector Analytical Study</value>
<type>PrincipalTitle</type>
</name>
<identifier>
<nonUriValue>10.46243/jst.2025.v10.i08.pp60-65</nonUriValue>
<uri returnType="text/html" doesContentNegotiation="true">https://doi.org/10.46243/jst.2025.v10.i08.pp60-65</uri>
<type>DOI</type>
</identifier>
<identifier>
<uri returnType="text/html">https://www.jst.org.in/index.php/pub/article/view/1475</uri>
<type>URI</type>
</identifier>
<identifier>
<uri>https://www.jst.org.in/index.php/pub/article/download/1475/1121</uri>
<type>URI</type>
</identifier>
<identifier>
<uri returnType="application/xml">https://www.jst.org.in/index.php/pub/article/download/1475/1205</uri>
<type>URI</type>
</identifier>
<identifier>
<uri>https://jst.org.in/index.php/pub/article/view/1475/1121</uri>
<type>URI</type>
</identifier>
<structuralType>Digital</structuralType>
<mode>Visual</mode>
<character>Language</character>
<type>JournalArticle</type>
<principalAgent>
<name>
<value>M.Kishore Babu</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>B.Sandhya Rani</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>I. Triveni</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>B.Revathi</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>Longman Publishers</value>
<type>PrincipalName</type>
</name>
<role>Publisher</role>
</principalAgent>
<linkedCreation>
<name>
<value>Journal of Science & Technology</value>
<type>PrincipalTitle</type>
</name>
<identifier>
<nonUriValue>2456-5660</nonUriValue>
<type>ISSN</type>
</identifier>
<referentCreationRole>Part</referentCreationRole>
<referentCreationSequenceIdentifier>
<value>10</value>
<type>VolumeNumber</type>
</referentCreationSequenceIdentifier>
<referentCreationSequenceIdentifier>
<value>08</value>
<type>IssueNumber</type>
</referentCreationSequenceIdentifier>
<referentCreationSequenceIdentifier>
<value>60-66</value>
<type>PageNumber</type>
</referentCreationSequenceIdentifier>
</linkedCreation>
<language>en</language>
<languageOfReferentContent>
<language>en</language>
<languageOfReferentContentType>Original</languageOfReferentContentType>
</languageOfReferentContent>
<creationDate>
<date>2025-08-02</date>
<creationDateType>PublicationDate</creationDateType>
</creationDate>
</referentCreation>
</kernelMetadata>
