Kernel Metadata Declaration — on demand
ISO 26324 asks a DOI Registration Agency to produce a Kernel Metadata Declaration for every DOI it issues. Give any DOI: its public record becomes a record in the Smart Scholars DOI Metadata Format 1.0, checked against every rule, and declared as the Kernel XML.
✓ Meets every rule of the format
The record below is complete and every controlled value is a DOI Attribute Value Set 2.3 spelling. The Declaration on the right follows DOIMetadataKernel.xsd element by element.
What the DOI identifies
Bioinformatics enriched analysis for identification of novel candidate genes and pathways for cystic fibrosis
10.46243/jst.2021.v6.i05.pp16-32 · JournalArticle — an article in a journal · Digital · Visual · Language · en
Published 2021-09-25
Part of Journal of Science & Technology · ISSN 2456-5660 · vol. 06 · no. 05 · pp. 16–32
Principal agents
- Aurobinda Das (author → Author)
- Suresh Kumar Panda (author → Author)
- Debakanta Sahoo (author → Author)
- Longman Publishers (publisher → Publisher)
Also in the record, outside the Kernel: the abstract, the licence, 4 links, 6 references. Source: Crossref (member 25296), registered 2026-09-12, last deposited 2026-09-20.
System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1
Each element by the standard's name and the Handbook's (in grey), read off the record.
| DOI Name DOI name | 10.46243/jst.2021.v6.i05.pp16-32 |
| Referent Type referentType | Creation |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal |
| Referent Name(s) referentName(s) | Bioinformatics enriched analysis for identification of novel candidate genes and pathways for cystic fibrosis (PrincipalTitle, en) |
| Basic Metadata basicMetadata | author: Aurobinda Das author: Suresh Kumar Panda author: Debakanta Sahoo publisher: Longman Publishers published: 2021-09-25 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 06 · no. 05 · pp. 16–32 language: en form: Digital · Visual · Language |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy |
| Created Date issueDate | 2026-09-12 |
| relatedIdentifiers | none needed — the descriptive metadata is in this record |
The record
{
"format": "smartscholars-doi-metadata/1.0",
"doi": "10.46243/jst.2021.v6.i05.pp16-32",
"referent": "Creation",
"type": "JournalArticle",
"structural_type": "Digital",
"modes": [
"Visual"
],
"characters": [
"Language"
],
"titles": [
{
"value": "Bioinformatics enriched analysis for identification of novel candidate genes and pathways for cystic fibrosis",
"type": "PrincipalTitle",
"lang": "en"
}
],
"identifiers": [
{
"type": "DOI",
"value": "10.46243/jst.2021.v6.i05.pp16-32"
}
],
"agents": [
{
"role": "author",
"name": {
"given": "Aurobinda",
"family": "Das"
},
"sequence": "first"
},
{
"role": "author",
"name": {
"given": "Suresh",
"family": "Kumar Panda"
},
"sequence": "additional"
},
{
"role": "author",
"name": {
"given": "Debakanta",
"family": "Sahoo"
},
"sequence": "additional"
},
{
"role": "publisher",
"name": {
"org": "Longman Publishers"
}
}
],
"dates": {
"published": "2021-09-25",
"date_type": "PublicationDate",
"online": "2021-09-25"
},
"language": "en",
"container": {
"type": "Journal",
"titles": [
{
"value": "Journal of Science & Technology",
"type": "PrincipalTitle"
}
],
"identifiers": [
{
"type": "ISSN",
"value": "2456-5660",
"medium": "electronic"
}
],
"volume": "06",
"issue": "05",
"pages": {
"first": "16",
"last": "32"
}
},
"links": [
{
"url": "https://www.jst.org.in/index.php/pub/article/view/933",
"return_type": "text/html",
"primary": true
},
{
"url": "https://www.jst.org.in/index.php/pub/article/download/933/860",
"purpose": "text-mining",
"return_type": "application/pdf"
},
{
"url": "https://www.jst.org.in/index.php/pub/article/download/933/2576",
"purpose": "text-mining",
"return_type": "application/xml"
},
{
"url": "https://www.jst.org.in/index.php/pub/article/view/933/860",
"purpose": "similarity-checking"
}
],
"abstract": {
"value": "Cystic Fibrosis, an inherited disorder, is primarily found in white American society. It arises due to alteration in the CFTR gene. Several pieces of evidence insight oxidative stress as one of the primary reasons behind this disorder. Thus, with the aim of finding the physiopathology of this disorder and its association with oxidative stress, a comparative transcriptomic study of CF with control was performed. A transcriptomic dataset (GSE ID: 39843) was accessed through Gene Expression Omnibus. Differentially Expressed Genes were enriched, and novel DEGs were sorted out. A protein-protein interaction network was constructed, followed by Gene Ontology and KEGG pathway enrichment. Our analysis revealed a total of 704 DEGs with 556 up-regulated and 148 downregulated genes. Comparison with the reported gene list (obtained through OMIM and Gene Cards) lead to the identification of 156 novel DEGs (125 up-regulated and 31 downregulated). PPI network constructed for the respective DEGs consists of 233 nodes and 1304 edges. POLR2D,CUL1,RAN,MANF,LNX1,GMNN, and STOM were identified as hub nodes through networking. GO and KEGG enrichment study identifies some major significant processes and pathways like Pyrimidine metabolism, Glutathione metabolism, Pentose phosphate pathway, Ubiquitin mediated proteolysis. ABC transporters up-regulated DEGs while cytokine receptor, Cell adhesion molecules, tight junction, leukocyte transendothelial for down-regulated DEGs. POLR2D,CUL1,RAN,MANF,LNX1,GMNN, and STOM genes may represent novel candidate biomarkers related to CF disease, as also revealed through our present findings. The current work reveals a new outlook to detect potential targets behind the cause of CF occurrence.",
"lang": "en"
},
"license": {
"url": "https://creativecommons.org/licenses/by/4.0/",
"start": "2021-09-25",
"applies_to": "vor"
},
"references": [
{
"key": "ref1",
"doi": "10.1016/j.ydbio.2013.12.034",
"unstructured": "C. de Renty, K.J. Kaneko, M.L. DePamphilis, The dual roles of geminin during trophoblast proliferation and differentiation, Developmental Biology. 387 (2014) 49–63. https://doi.org/10.1016/j.ydbio.2013.12.034"
},
{
"key": "ref2",
"doi": "10.1016/j.biochi.2016.09.022",
"unstructured": "P.P. Kushwaha, K.C. Rapalli, S. Kumar, Geminin a multi-task protein involved in cancer pathophysiology and developmental process: A review, Biochimie. 131 (2016) 115–127. https://doi.org/10.1016/j.biochi.2016.09.022"
},
{
"key": "ref3",
"doi": "10.1002/mc.20441",
"unstructured": "M.R. Salabat, L.G. Melstrom, M.J. Strouch, X.-Z. Ding, B.M. Milam, M.B. Ujiki, C. Chen, J.C. Pelling, S. Rao, P.J. Grippo, T.J. McGarry, D.J. Bentrem, Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid apigenin in pancreatic cancer cell lines, Mol. Carcinog. 47 (2008) 835–844. https://doi.org/10.1002/mc.20441"
},
{
"key": "ref4",
"doi": "10.1016/j.biopha.2019.108661",
"unstructured": "P.R. Manzine, M. Ettcheto, A. Cano, O. Busquets, E. Marcello, S. Pelucchi, M. Di Luca, K. Endres, J. Olloquequi, A. Camins, M.R. Cominetti, ADAM10 in Alzheimer’s disease: Pharmacological modulation by natural compounds and its role as a peripheral marker, Biomedicine & Pharmacotherapy. 113 (2019) 108661. https://doi.org/10.1016/j.biopha.2019.108661"
},
{
"key": "ref5",
"doi": "10.18632/oncotarget.7836",
"unstructured": "M. Müller, S. Wetzel, J. Köhn-Gaone, K. Chalupsky, R. Lüllmann-Rauch, R. Barikbin, J. Bergmann, B. Wöhner, O. Zbodakova, I. Leuschner, G. Martin, G. Tiegs, S. Rose-John, R. Sedlacek, J.E.E. Tirnitz-Parker, P. Saftig, D. Schmidt-Arras, A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis, Oncotarget. 7 (2016) 17431–17441. https://doi.org/10.18632/oncotarget.7836. P age 22 Published by: Longman Publishers www.jst.org.in"
},
{
"key": "ref6",
"doi": "10.1371/journal.pone.0001651",
"unstructured": "M.T. Landi, T. Dracheva, M. Rotunno, J.D. Figueroa, H. Liu, A. Dasgupta, F.E. Mann, J. Fukuoka, M. Hames, A.W. Bergen, S.E. Murphy, P. Yang, A.C. Pesatori, D. Consonni, P.A. Bertazzi, S. Wacholder, J.H. Shih, N.E. Caporaso, J. Jen, Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival, PLoS ONE. 3 (2008) e1651. https://doi.org/10.1371/journal.pone.0001651"
}
],
"record": {
"registrant": "Longman Publishers",
"registered": "2026-09-12",
"updated": "2026-09-20",
"issue_number": 1,
"source": "crossref-api",
"source_agency": "Crossref (member 25296)"
}
}The Kernel Metadata Declaration
DOIMetadataKernel.xsd · namespace http://www.doi.org/2010/DOISchema · Attribute Value Sets 2.3 · draft — the agency's DOI name is filled in on accreditation
<?xml version="1.0" encoding="UTF-8"?>
<!-- DRAFT declaration: Smart Scholars is not yet a DOI Registration Agency. registrationAgencyDoiName is a marker (10.0/ is no RA's prefix) and is filled in on accreditation. -->
<kernelMetadata xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.doi.org/2010/DOISchema https://www.doi.org/doi_schemas/DOIMetadataKernel.xsd" xmlns="http://www.doi.org/2010/DOISchema">
<referentDoiName>10.46243/jst.2021.v6.i05.pp16-32</referentDoiName>
<primaryReferentType>Creation</primaryReferentType>
<registrationAgencyDoiName>10.0/smart-scholars-draft</registrationAgencyDoiName>
<issueDate>2026-10-04</issueDate>
<issueNumber>1</issueNumber>
<referentCreation>
<name primaryLanguage="en">
<value>Bioinformatics enriched analysis for identification of novel candidate genes and pathways for cystic fibrosis</value>
<type>PrincipalTitle</type>
</name>
<identifier>
<nonUriValue>10.46243/jst.2021.v6.i05.pp16-32</nonUriValue>
<uri returnType="text/html" doesContentNegotiation="true">https://doi.org/10.46243/jst.2021.v6.i05.pp16-32</uri>
<type>DOI</type>
</identifier>
<identifier>
<uri returnType="text/html">https://www.jst.org.in/index.php/pub/article/view/933</uri>
<type>URI</type>
</identifier>
<identifier>
<uri>https://www.jst.org.in/index.php/pub/article/download/933/860</uri>
<type>URI</type>
</identifier>
<identifier>
<uri returnType="application/xml">https://www.jst.org.in/index.php/pub/article/download/933/2576</uri>
<type>URI</type>
</identifier>
<identifier>
<uri>https://www.jst.org.in/index.php/pub/article/view/933/860</uri>
<type>URI</type>
</identifier>
<structuralType>Digital</structuralType>
<mode>Visual</mode>
<character>Language</character>
<type>JournalArticle</type>
<principalAgent>
<name>
<value>Aurobinda Das</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>Suresh Kumar Panda</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>Debakanta Sahoo</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>Longman Publishers</value>
<type>PrincipalName</type>
</name>
<role>Publisher</role>
</principalAgent>
<linkedCreation>
<name>
<value>Journal of Science & Technology</value>
<type>PrincipalTitle</type>
</name>
<identifier>
<nonUriValue>2456-5660</nonUriValue>
<type>ISSN</type>
</identifier>
<referentCreationRole>Part</referentCreationRole>
<referentCreationSequenceIdentifier>
<value>06</value>
<type>VolumeNumber</type>
</referentCreationSequenceIdentifier>
<referentCreationSequenceIdentifier>
<value>05</value>
<type>IssueNumber</type>
</referentCreationSequenceIdentifier>
<referentCreationSequenceIdentifier>
<value>16-32</value>
<type>PageNumber</type>
</referentCreationSequenceIdentifier>
</linkedCreation>
<language>en</language>
<languageOfReferentContent>
<language>en</language>
<languageOfReferentContentType>Original</languageOfReferentContentType>
</languageOfReferentContent>
<creationDate>
<date>2021-09-25</date>
<creationDateType>PublicationDate</creationDateType>
</creationDate>
</referentCreation>
</kernelMetadata>
