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Effects and Mechanism of Nanotoxicity:An Overview

10.46243/jst.2021.v6.i04.pp58-68 · JournalArticle — an article in a journal · Digital · Visual · Language · en

Published 2021-07-14

Part of Journal of Science & Technology · ISSN 2456-5660 · vol. 06 · no. 04 · pp. 58–68

Principal agents

• Ms. Isha Jain (author → Author)
• Ms. Priyanka Patel (author → Author)
• Longman Publishers (publisher → Publisher)

Also in the record, outside the Kernel: the abstract, the licence, 4 links, 79 references. Source: Crossref (member 25296), registered 2026-09-08, last deposited 2026-09-20.

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The record

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        "volume": "06",
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    "abstract": {
        "value": "Nanotechnology is a rapidly developing field of 21st century, which has provided groundbreaking discoveries in many areas, including the medical, industrial, and consumer sectors. The unique characteristics of engineered nanoparticles (NPs) have paved their way in a variety of applications. However, these novel properties of NPs are filled with concerns for their potential toxicity. At present, more than a hundred different types of NPs are known, but there is no well-defined guideline to estimate their potential risk. Information concerning their safety is urgently needed and that is why for the past few decades, there has been a remarkable increase in this research area of the field of nanotoxicology. NPs have been studied intensively for their cell toxicity, genotoxicity, and immunotoxicity. One of the widely accepted mechanism of nanotoxicity is the generation of reactive oxygen species (ROS). Present review selectively focuses on the harmful effects and mechanisms of NP toxicity.",
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        {
            "key": "ref1",
            "doi": "10.3390/molecules25010112",
            "unstructured": "Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio F. The History of Nanoscience and Nanotechnology: From Chemical-Physical Applications to Nanomedicine. Molecules. 2019;25(1):112"
        },
        {
            "key": "ref2",
            "unstructured": "Berube, David &Searson, E.M. & Morton, T.S. & Cummings, Christopher. Project on emerging nanotechnologies-Consumer product inventory evaluated. Nanotechnology Law and Business. 2010; 7. 152-163"
        },
        {
            "key": "ref3",
            "doi": "10.1039/b818082b",
            "unstructured": "Marquis, Bryce & Love, Sara & Braun, Katherine & Haynes, Christy. Analytical Methods to Assess Nanoparticle Toxicity. The Analyst. 2009; 134. 425-39"
        },
        {
            "key": "ref4",
            "doi": "10.1002/smll.202000603",
            "unstructured": "Liu, Sijin& Xia, Tian. Continued Efforts on Nanomaterial‐Environmental Health and Safety Is Critical to Maintain Sustainable Growth of Nanoindustry. Small. 2020; 16"
        },
        {
            "key": "ref5",
            "doi": "10.1093/acref/9780191826719.001.0001",
            "unstructured": "Roy Amara. In Ratcliffe, S. (Ed.), Oxford Essential Quotations. : Oxford University Press"
        },
        {
            "key": "ref6",
            "doi": "10.1016/j.wasman.2009.04.001",
            "unstructured": "Bystrzejewska-Piotrowska G, Golimowski J, Urban PL. Nanoparticles: their potential toxicity, waste and environmental management. Waste Manag. 2009;29(9):2587-2595"
        },
        {
            "key": "ref7",
            "doi": "10.1116/1.2815690",
            "unstructured": "Buzea C, Pacheco II, Robbie K. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases. 2007;2(4):MR17-MR71"
        },
        {
            "key": "ref8",
            "doi": "10.1089/089426802320282338",
            "unstructured": "Ken Donaldson, David Brown, Anna Clouter, Rodger Duffin, William MacNee, Louise Renwick, Lang Tran, and Vicki Stone. The pulmonary toxicology of ultrafine particles. Journal of Aerosol Medicine. 2002.213-220"
        },
        {
            "key": "ref9",
            "doi": "10.1126/science.1108752",
            "unstructured": "Nel, A. Air pollution-related illness: effects of particles. Science. 2005; 308, 804–806"
        },
        {
            "key": "ref10",
            "doi": "10.1136/oem.2004.013243",
            "unstructured": "Donaldson K, Stone V, Tran C, Kreyling W, Borm PJ. Nanotoxicology. Occup. Environ. Med. 2004; 61, 727–728"
        },
        {
            "key": "ref11",
            "doi": "10.1289/ehp.7339",
            "unstructured": "Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005; 823–839"
        },
        {
            "key": "ref12",
            "doi": "10.1289/ehp.112-a740",
            "unstructured": "Hood E. Nanotechnology: looking as we leap. Environ Health Perspect. 2004;112(13):A740-9"
        },
        {
            "key": "ref13",
            "doi": "10.1080/17435390902725914",
            "unstructured": "Wijnhoven SW, Peijnenburg WJ, Herberts CA, Hagens WI, Oomen AG, et al. Nano-silver–a review of available data and knowledge gaps in human and environmental risk assessment. Nanotoxicology. 2009;3(2):109-138"
        },
        {
            "key": "ref14",
            "doi": "10.4172/2157-7439.s6-001",
            "unstructured": "Abideen S, Sankar M. In-vitro Screening of Antidiabetic and Antimicrobial Activity against Green Synthesized AgNO3 using Seaweeds. J Nanomed Nanotechnol S6-001. doi. 2015;10:2157-7439"
        },
        {
            "key": "ref15",
            "doi": "10.1063/1.1555312",
            "unstructured": "Chen M, Yamamuro S, Farrell D, Majetich SA. Gold-coated iron nanoparticles for biomedical applications. Journal of applied physics. 2003 May 15;93(10):7551-3"
        },
        {
            "key": "ref16",
            "doi": "10.1039/c2cs15337h",
            "unstructured": "Colombo M, Carregal-Romero S, C asula MF, Gutiérrez L, Morales MP, Böhm IB, Heverhagen JT, Prosperi D, Parak WJ. Biological applications of magnetic nanoparticles. Chemical Society Reviews. 2012;41(11):4306-34"
        },
        {
            "key": "ref17",
            "doi": "10.1177/004051750407400202",
            "unstructured": "Xin JH, Daoud WA, Kong YY. A new approach to UV-blocking treatment for cotton fabrics. Text Res J. 2004; 74:97–100"
        },
        {
            "key": "ref18",
            "doi": "10.1039/b702887c",
            "unstructured": "Qi K, Chen X, Liu Y, Xin JH, Mak CL, Daoud WA. Facile preparation of anatase/SiO2 spherical nanocomposites and their application in self-cleaning textiles. J Mater Chem. 2007; 17:3504–3508"
        },
        {
            "key": "ref19",
            "doi": "10.1007/s11051-007-9318-3",
            "unstructured": "Becheri A, Dürr M, Nostro P L, Baglioni P. Synthesis and characterization of zinc oxide nanoparticles: application to textiles as UV-absorbers. Journal of Nanoparticle Research. 2008;10(4):679-89"
        },
        {
            "key": "ref20",
            "unstructured": "Suleiman M, Al Ali A, Hussein A, Hammouti B, Hadda TB, Warad I. Sulfur nanoparticles: Synthesis, characterizations and their applications. J. Mater. Environ. Sci. 2013;4(6):1029-33"
        },
        {
            "key": "ref21",
            "doi": "10.1016/j.materresbull.2007.07.045",
            "unstructured": "Li L, Liang J, Tao Z, Chen J. Cupric oxide particles and plates: synthesis and gas-sensor application. Mater Res Bull. 2008; 43:2380–2385"
        },
        {
            "key": "ref22",
            "doi": "10.1007/s10529-013-1239-x",
            "unstructured": "Rubilar O, Rai M, Tort ella G, Diez MC, Seabra AB, Durán N. Biogenic nanoparticles: copper, copper oxides, copper sulphides, complex copper nanostructures and their applications. Biotechnology Letters. 2013 Sep;35(9):1365-75"
        },
        {
            "key": "ref23",
            "doi": "10.1007/s13205-019-1577-z",
            "unstructured": "Mahato K, Nagpal S, Shah MA, Srivastava A, Maurya PK, Roy S, Jaiswal A, Singh R, Chandra P. Gold nanoparticle surface engineering strategies and their applications in biomedicine and diagnostics. 3 Biotech. 2019;9(2):57"
        },
        {
            "key": "ref24",
            "doi": "10.1002/smll.201303329",
            "unstructured": "Cheng Y, Doane TL, Chuang CH, Ziady A, Burda C. Near infrared light‐triggered drug gene ration and release from gold nanoparticle carriers for photodynamic therapy. Small. 2014;10(9):1799-804"
        },
        {
            "key": "ref25",
            "doi": "10.1016/j.ijpharm.2014.05.061",
            "unstructured": "Bansal V, Kumar M, Dalela M, Brahmne HG, Singh H. Evaluation of synergistic effect of biodegradable polymeric nanoparticles and aluminum based adjuvant for improving vaccine efficacy. International journal of pharmaceutics. 2014 Aug 25;471(1-2):377-84"
        },
        {
            "key": "ref26",
            "doi": "10.1016/j.ccr.2016.02.017",
            "unstructured": "LeCroy GE, Yang ST, Yang F, Liu Y, Fernando KS, Bunker CE, Hu Y, Luo PG, Sun YP. Functionalized carbon nanoparticles: Syntheses and applications in optical bioimaging and energy conversion. Coordination Chemistry Reviews. 2016;320:66-81"
        },
        {
            "key": "ref27",
            "unstructured": "Maynard A D. A research s trategy for addressing risk. Nanotechnology, Woodrow Wilson Internationa l Center for Scholars. 2006;444, 267–269"
        },
        {
            "key": "ref28",
            "doi": "10.1126/science.1114397",
            "unstructured": "Nel A, Xia T, Mädler L, Li N. Toxic potential of materials at the nanolevel. Science. 2006;311, 622–627"
        },
        {
            "key": "ref29",
            "doi": "10.1007/s12031-012-9756-y",
            "unstructured": "Kao YY, Cheng TJ, Yang DM, Wang CT, C hiung YM, Liu PS. Demonstration of an olfactory bulb-brain translocation pathway for ZnO nanoparticles in rodent cells in vitro and in vivo. J Mol Neurosci. 2012;48(2):464-471"
        },
        {
            "key": "ref30",
            "doi": "10.3389/fpls.2018.00872",
            "unstructured": "Mosa KA, El-Naggar M, Ramamoorthy K, Alawadhi H, Elnaggar A, et al. Copper Nano particles Induced Genotoxicty, Oxidative Stress, and Changes in Superoxide Dismutase (SOD) Gene Expression in Cucumber (Cucumis sativus) Plants. Frontiers in plant science. 2018; 9, 872"
        },
        {
            "key": "ref31",
            "doi": "10.1016/j.yrtph.2007.07.006",
            "unstructured": "Hagens WI, Oomen AG, de Jong WH, Casse FR, Sips AJ. What do we need t o know about the kinetic properties of nanoparticles in the body? Regulatory toxicology and pharmacology. 2007;49(3):217–229"
        },
        {
            "key": "ref32",
            "doi": "10.1161/hc0402.104118",
            "unstructured": "Nemmar A, Hoet PH, Vanquickenborne B, Dinsdale D, Thomeer M, Hoylaerts MF, Vanbilloen H, Mortelmans L, Nemery B. Passage of inhale d particles into the blood circulation in humans. Circulation. 2002;105(4):411–414"
        },
        {
            "key": "ref33",
            "doi": "10.1289/ehp.01109s4547",
            "unstructured": "Takenaka S, Karg E, Roth C, Schulz H, Ziesenis A, Heinzmann U, Schramel P, Heyder J. Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Envi ronmental health perspectives. 2001;109(4):547–551"
        },
        {
            "key": "ref34",
            "doi": "10.1016/j.colsurfb.2014.06.064",
            "unstructured": "Dwivedi S, Siddiqui MA, Farshori NN, Ahamed M, Musarrat J, Al-Khedhairy AA. Synthesis, characterization and toxicological evaluation of iron oxide nanoparticles in human lung alveolar epithelial cells. Colloids Surf B Biointerfaces. 2014;122:209-215"
        },
        {
            "key": "ref35",
            "doi": "10.1016/j.toxlet.2005.10.003",
            "unstructured": "Chen Z, Meng H, Xing G, Chen C, Zhao Y, Jia G, Wang T, Yuan H, Ye C, Zhao F, Chai Z, Zhu C, Fang X, Ma B, Wan L. Acute toxicological effects of copper nanoparticles in vivo. Toxicol Lett. 2006;163(2):109-20"
        },
        {
            "key": "ref36",
            "doi": "10.1164/rccm.200406-837oc",
            "unstructured": "Beckett WS, Chalupa DF, Pauly-Brown A, Speers DM., Stewart JC, et al. Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study. Am. J. Resp. Crit. Care Med. 2005;171, 1129–1135"
        },
        {
            "key": "ref37",
            "doi": "10.1007/s11051-005-3473-1",
            "unstructured": "Soto KF, Carrasco A, Powell TG et al. Comparative in vitro cytotoxicity assessment of some manufacturednanoparticulate materials characterized by transmission electron mi croscopy. J Nanopart Res. 2005;7:145–169"
        },
        {
            "key": "ref38",
            "doi": "10.5455/vetworld.2011.35-40",
            "unstructured": "Jain S, Sahni Y & Gautam N. Nanotoxicology: An Emerging Discipline. Veterinary World. 2011;4"
        },
        {
            "key": "ref39",
            "doi": "10.1016/s0142-9612(03)00537-4",
            "unstructured": "Gatti AM. Biocompatibility of micro-and nano-particles in the colon. Biomaterials. 2004;25:385–392"
        },
        {
            "key": "ref40",
            "doi": "10.1021/tx800064j",
            "unstructured": "Karlsson HL, Cronholm P, Gustafsson J, Moller L. Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparti cles and carbon nanot ubes. Chem. Res. Toxicol. 2008;21: 1726–1732"
        },
        {
            "key": "ref41",
            "doi": "10.1016/j.bbadis.2006.09.011",
            "unstructured": "Hautot D, Pankhurst QA, Morris CM, C urtis A, Burn J, Dobson J. Preliminary observation of elevated levels of nanocrystalline iron oxide in the basal ganglia of neuroferritinopathy patients. Biochimica et Biophysica Acta (BBA). 2007;1772:21–25"
        },
        {
            "key": "ref42",
            "doi": "10.1021/es052069i",
            "unstructured": "Brunner TJ, Wick P, Manser P, Spohn P, Grass RN, Limbach LK, Bruinink A, Stark WJ. In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility. Environmental science & technology. 2006;40(14):4374-81"
        },
        {
            "key": "ref43",
            "doi": "10.1080/17435390701314761",
            "unstructured": "Oberdörster G, Stone V, Donaldson K. Toxicology of nanoparticles: a historical perspective. Nanotoxicology. 2007;1:2–25"
        },
        {
            "key": "ref44",
            "doi": "10.2217/nnm.09.20",
            "unstructured": "Singh N. Conference scene-nanotoxicology: health and environment al impacts. Nano medicine. 2009;4:385–390"
        },
        {
            "key": "ref45",
            "doi": "10.3402/nano.v1i0.5358",
            "unstructured": "Singh N, Jenkins GJ, Asadi R, Doak SH. Potential toxicity of superparamagnetic iron oxide nanopar ticles (SPION). Nano Rev. 2010;1:5358"
        },
        {
            "key": "ref46",
            "unstructured": "Lucarelli M, Gatti AM, Savarino G, Quattroni P, et al. Innate defence functions of macrophage s can be biased by nano-sized ceramic and metallic particles. Eur. Cytokine Netw. 2004;15:339–346"
        },
        {
            "key": "ref47",
            "doi": "10.1002/ijc.20064",
            "unstructured": "Borm PJ, Schins RP, Albrecht C. Inhaled particles and lung cancer, part B: paradigms and risk assessment. Int. J. Cancer. 2004;110:3–14"
        },
        {
            "key": "ref48",
            "doi": "10.1016/0378-4274(96)03712-5",
            "unstructured": "Dasenbrock C, Peters L, Creutzenberg O, Heinrich U. The carcinogenic potency of carbon particles with and without PAH after repeated intratracheal administration in the rat. Toxicol. Lett. 1996;88 :15–21"
        },
        {
            "key": "ref49",
            "doi": "10.1006/taap.1996.0045",
            "unstructured": "Driscoll KE, Carter J M, Howard B W, Hassenbein DG, Pepelko W, Baggs RB, Oberdörster G. Pulmonary inflammatory, chemokine, and mutagenic responses in rats after subchronic inhalation of carbon blac k. Toxicol. Appl. Pharma. 1996;136:372–380"
        },
        {
            "key": "ref50",
            "doi": "10.1016/0378-4274(94)90018-3",
            "unstructured": "Ferin J. Pulmonary retention and clearance of particles. Toxicology Lett. 1994;72:121–125"
        },
        {
            "key": "ref51",
            "doi": "10.1093/toxsci/25.1.80",
            "unstructured": "Nikula K, Snipes M., Barr E, Griffith W, Henderson R., Mauderly J. Comparative pulmonary toxicities and carcinogenicities of chronically inhaled diesel exhaust and carban black in F344 rats. Toxicol. Sci. 1995;25:80–94"
        },
        {
            "key": "ref52",
            "doi": "10.1289/ehp.94102s5173",
            "unstructured": "Oberdörster G, Ferin J, Lehnert BE. Correlation between particle size, in vivo particle persistence, and lung injury. Environ. Health Perspect. 1994;102:173"
        },
        {
            "key": "ref53",
            "doi": "10.1016/j.envpol.2008.10.002",
            "unstructured": "Auffan M, Rose J, Wiesner MR, Bottero J Y. Chemical stability of metallic nanoparticles: a parameter controlling their potential cellular toxicity in vitro. Environ. Pollut. 2009;157:1127–1133"
        },
        {
            "key": "ref54",
            "doi": "10.1016/j.watres.2006.08.004",
            "unstructured": "Adams, L.K., Lyon, D.Y., Alvarez, P.J. Comparative eco-toxicity of nanoscale TiO2, SiO2, and ZnO wate r suspensions. Water Res. 2006;40:3527–3532"
        },
        {
            "key": "ref55",
            "doi": "10.1007/s004200000185",
            "unstructured": "Oberdörster G. Pulmonary effects of inhaled ultrafine particles. Int. Arch. Occup. Environ. Health. 2000;74:1–8"
        },
        {
            "key": "ref56",
            "doi": "10.1186/1743-8977-3-11",
            "unstructured": "Borm PJ, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, Schins R, Stone V, Kreyling W, Lademann J, Krutmann J. The potential risks of nanomaterials: a review carried out for EC ETOC. Particle and fibre toxicology. 2006;3(1):1-35"
        },
        {
            "key": "ref57",
            "doi": "10.1111/j.0022-202x.2004.22717.x",
            "unstructured": "Toll R, Jacobi U, Richter H, Lademann J, Schaefer H, Blume-Peytavi U. Penetration profile of microspheres in follicular targeting of terminal hair follicles. Journal of Investigative Dermatology. 2004;123(1):168-176"
        },
        {
            "key": "ref58",
            "doi": "10.1053/gast.2001.29333",
            "unstructured": "Ballestri M, Baraldi A, Gatti AM, Furci L, Bagni A, Loria P, Rapanà RM, Carulli N, Albertazzi A. Liver and kidney foreign bodies granulomatosis in a patient with malocclusion, bruxism, and worn dental prostheses. Gastroenterology. 2001;121(5):1234-1238"
        },
        {
            "key": "ref59",
            "doi": "10.1038/sj.bjp.0707130",
            "unstructured": "Medina C, Santos‐Martinez MJ, Radomski A, Corrigan OI, Radomski MW. Nanoparticles: pharmacological and toxicological significance. British journal of pharmacology. 2007;150(5):552-8"
        },
        {
            "key": "ref60",
            "doi": "10.1016/j.tiv.2009.12.001",
            "unstructured": "Park EJ, Yi J, Kim Y, Choi K, Park K. Silver nanoparticles in duce cytotoxicity by a Trojan-horse type mechanism. Toxicology in vitro. 2010;24(3):872-878"
        },
        {
            "key": "ref61",
            "doi": "10.2147/ijn.s26592",
            "unstructured": "Oh N and Park J H. Endocytosis and exocytosis of nanoparticles in mammalian cells. Int. J. Nanomed. 2014; 9(Suppl 1):51"
        },
        {
            "key": "ref62",
            "doi": "10.1021/nn9005973",
            "unstructured": "Meng H, Xia T, George S, Nel AE. A predicti ve toxicological paradigm for the safety assessment of nanomaterials. ACS Nano. 2009;3(7):1620-1627"
        },
        {
            "key": "ref63",
            "doi": "10.1021/tx960133r",
            "unstructured": "Stadtman ER and Berlett BS. Reactive oxygen-mediated protein oxidation in aging and disease. Chem Res Toxicol. 1997;10(5):485-94"
        },
        {
            "key": "ref64",
            "doi": "10.1016/j.nano.2011.01.002",
            "unstructured": "Wu YN, Chen DH, Shi XY, Lian CC, Wang TY, Yeh CS, Ratinac KR, Thordarson P, Braet F, Shieh DB. Cancer-cell-specific cytotoxicity of non-oxidized iron elements in iron core-gold shell NPs. Nanomedicine. 2011;7(4):420–427"
        },
        {
            "key": "ref65",
            "doi": "10.1016/j.mrfmmm.2005.06.012",
            "unstructured": "Risom L, Møller P, Loft S. Oxidative stress-induced DNA damage by particulate air pollution. Mutation Res. 2005;592, 119–137"
        },
        {
            "key": "ref66",
            "doi": "10.1016/j.cbi.2005.12.009",
            "unstructured": "Valko M, Rhodes CJ, Moncol J, Izakovic M, and Mazur M. Free radicals, metals and antioxidants in oxidative stress induced cancer. Chemico-Biological Interactions. 2006;160(1):1–40"
        },
        {
            "key": "ref67",
            "doi": "10.1002/ijc.11708",
            "unstructured": "Knaapen AM, Borm PJ, Albrecht C, and Schins RP. Inhaled particles and lung cancer, part A: mechanisms. International Journal of Cancer. 2004;109(6):799–809"
        },
        {
            "key": "ref68",
            "doi": "10.1021/nl061025k",
            "unstructured": "Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett. 2006;(8):1794-807"
        },
        {
            "key": "ref69",
            "doi": "10.1016/j.toxlet.2012.08.009",
            "unstructured": "Xue Y, Wu J, Sun J. Four types of inorganic nanopart icles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro. Toxicol. Lett. 2012;214, 91–98"
        },
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            "doi": "10.1016/j.toxlet.2014.02.024",
            "unstructured": "Roy R, Singh SK, Chauhan L, Das M, Tripathi A, Dwivedi PD. Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/ mTOR inhibition. Toxicol. Lett. 2014;227, 29–40"
        },
        {
            "key": "ref71",
            "doi": "10.1021/nn5008572",
            "unstructured": "Huo S, Jin S, Ma X, Xue X, Yang K, Kumar A, Wang PC, Zhang J, Hu Z, Liang XJ. Ultrasmall gold nanoparticles as carriers for nucleus-based gene therapy due to size-dependent nuclear entry. ACS Nano. 2014;8(6):5852-62"
        },
        {
            "key": "ref72",
            "doi": "10.1016/j.biomaterials.2007.12.037",
            "unstructured": "De Jong WH, Hagens WI, Krystek P, Burger MC, Sips AJ, Geertsma RE. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials. 2008;29:1912–1919"
        },
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            "key": "ref73",
            "doi": "10.1007/s00204-012-0827-1",
            "unstructured": "Zhao X, Ng S, Heng BC, Guo J, Ma L, T an TT, Ng KW, Loo SC. Cytotoxicity of hydroxyapatite nanoparticles is shape and cell dependent. Arch Toxicol. 2013;87(6):1037-52"
        },
        {
            "key": "ref74",
            "doi": "10.1021/es071445r",
            "unstructured": "Franklin NM, Rogers NJ, Apte SC, Batley GE, Gadd GE, Casey PS. Comparative toxicity of nanoparticulate ZnO, bulk ZnO, and ZnC l2 to a freshwater microalga (Pseudokirchneriellasubcapitata): the importance of particle solubility. Environ Sci Technol. 2007;41(24):8484-90"
        },
        {
            "key": "ref75",
            "doi": "10.1002/smll.201201593",
            "unstructured": "Zhu X, Hondroulis E, Liu W, Li CZ. Biosensing approaches for rapid genotoxicity and cytotoxicity assays upon nanomaterial exposure. Small. 2013;9(9-10):1821-30"
        },
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            "doi": "10.1186/s11671-018-2457-x",
            "unstructured": "Sukhanova A, Bozrova S, Sokolov P, Berestovoy M, Karaulov A, Nabiev I. Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties. Nanoscale Res Lett. 2018;13(1):44"
        },
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            "key": "ref77",
            "doi": "10.1016/b978-0-323-52733-0.00018-5",
            "unstructured": "Crisponi G, Nurchi V, & Lachowicz J, Peana M, Medici S, Zoroddu M. Toxicity of Nanoparticles: Etiology and Mechanisms. 2017"
        },
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            "key": "ref78",
            "doi": "10.1016/j.jfda.2014.01.005",
            "unstructured": "Fu P, Xia Q, Hwang Huey-Min, Ray P, Yu H. Mechanisms of nanotoxicity: Generation of reactive oxygen species. Journal of food and drug analysis. 2014;1;22(1):64-75"
        },
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            "key": "ref79",
            "doi": "10.1155/2013/942916",
            "unstructured": "Manke A, Wang L. & Rojanasakul Y. Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity. BioMed research international. 2013"
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The Kernel Metadata Declaration

DOIMetadataKernel.xsd · namespace http://www.doi.org/2010/DOISchema · Attribute Value Sets 2.3 · draft — the agency's DOI name is filled in on accreditation

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