Kernel Metadata Declaration — on demand

What the DOI identifies

Effect of Aescin on Inflammatory Responses in a Diabetic Peripheral Neuropathy Rat Model by Modulating HMGB1 and RAGE Levels

10.46243/jst.2021.v6.i03.pp240-246 · JournalArticle — an article in a journal · Digital · Visual · Language · en

Published 2021-06-27

Part of Journal of Science & Technology · ISSN 2456-5660 · vol. 06 · no. 03 · pp. 240–246

Principal agents

• T.Swathi (author → Author)
• T.Vijayalakshmi (author → Author)
• Maheen Zuberiya (author → Author)
• Longman Publishers (publisher → Publisher)

Also in the record, outside the Kernel: the abstract, the licence, 4 links, 18 references. Source: Crossref (member 25296), registered 2026-09-12, last deposited 2026-09-20.

⬇ Record (JSON) ⬇ Declaration (XML)

System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1

Each element by the standard's name and the Handbook's (in grey), read off the record.

The record

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        "value": "The diabetic peripheral neuropathy pain model was constructed after 95 Sprague Dawley rats had been randomly divided among blank reference and model groups. Aescin low-dose group (0.5 mg/kg), aescin medium-dose group (1.0 mg/kg), aescin high-dose group (1.5 mg/kg), and positive control group (0.25 mg/ kg mecobalamin) were then randomly assigned to the simulation group following successful modeling. At the conclusion of the study, the mean sciatic nerve conduction velocity was determined, blood glucose in addition to the amount of inflammatory factors tumor necrosis factor-alpha, interleukin-6, and interleukin-1 were determined, and sciatic nerve cells from mice in all groups were collected for Western blot to identify the protein levels of high mobility group box 1 and receptor for advanced glycation end products. The mean sciatic nerve conduction velocity of the medium and high-dose groups of aescin was higher than those of the model control (p<0.05); rat blood glucose content, the contents of inflammatory factors interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha as well as the protein expression of high mobility group box 1 and receptor for advanced glycation end products in sciatic nerve tissue were lower and the body mass was higher than that of the model control group (p<0.05). Comparing the high-dose aescin group as well as the positive control group, there had been no discernible change in the aforementioned indices (p>0.05). Aescin is able to effectively improve the inflammatory response in the body by regulating high mobility group box 1-receptor for advanced glycation end products levels and slow down diabetic peripheral neuropathy caused by the inflammatory response.",
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            "unstructured": "of diabetic peripheral neuropathy in patients with type 2 diabetes. Exp Clin Endocrinol Diabetes"
        },
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            "doi": "10.1056/nejmcp1503948",
            "unstructured": "Vinik AI. Diabetic sensory and motor neuropathy. New Engl J Med 2016;374(15):1455-64"
        },
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            "key": "ref4",
            "unstructured": "Zhou Y, Liu SX, Zhou YN, Wang J, Ji R. Research on the relationship between RAGE and its ligand HMGB1, and"
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            "key": "ref5",
            "unstructured": "prognosis and pathogenesis of gastric cancer with diabetes mellitus. Eur Rev Med Pharmacol Sci"
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            "unstructured": "Han R, Liu Z, Sun N, Liu S, Li L, Shen Y, et al. BDNF alleviates neuroinflammation in the hippocampus of type 1"
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            "doi": "10.14336/ad.2018.0707",
            "unstructured": "diabetic mice via blocking the aberrant HMGB1/RAGE/NF- κB pathway. Aging Dis 2019;10(3):611-25"
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            "unstructured": "Fukumoto J, Cox Jr R, Fukumoto I, Cho Y, Parthasarathy PT, Galam L, et al. Deletion of ASK1 protects against"
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            "unstructured": "acute lung injury. Respir Med 2016;119:23-8"
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            "key": "ref13",
            "unstructured": "Chen Z, Yu S. Protective effect and mechanism of aescin against blood-retinal barrier damage in diabetic rats"
        },
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            "key": "ref14",
            "unstructured": "Zhejiang J Integr Tradit Chin Med Western Med 2019;29(7):530-3"
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            "key": "ref15",
            "doi": "10.3389/fimmu.2018.02160",
            "unstructured": "Gupta SC, Kunnumakkara AB, Aggarwal S, Aggarwal BB. Inflammation, a double-edge sword for cancer and"
        },
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            "key": "ref16",
            "unstructured": "other age-related diseases. Front Immunol 2018;9(2):2160"
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            "doi": "10.1016/j.ejphar.2018.09.033",
            "unstructured": "Cheng CL, Chao WT, Li YH, Ou YC, Wang SS, Chiu KY, et al. Escin induces apoptosis in human bladder cancer"
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            "doi": "10.1016/j.ejphar.2018.09.033",
            "unstructured": "cells: An in vitro and in vivo study. Eur J Pharmacol 2018;840:79-88"
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The Kernel Metadata Declaration

DOIMetadataKernel.xsd · namespace http://www.doi.org/2010/DOISchema · Attribute Value Sets 2.3 · draft — the agency's DOI name is filled in on accreditation

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