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What the DOI identifies

Development and Charecterization of Caffeine and Quercetin Loaded Nasal Niosomal In-Situ Gel for Treatment of Depression

10.46243/jst.2020.v5.i5.pp171-187 · JournalArticle — an article in a journal · Digital · Visual · Language · en

Published 2020-10-14

Part of Journal of Science & Technology · ISSN 2456-5660 · no. Volume 5 · pp. 171–187

Principal agents

• P.Shilpa Chaudhari (author → Author)
• U. Sneha Gaikwad (author → Author)
• Longman Publishers (publisher → Publisher)

Also in the record, outside the Kernel: the abstract, the licence, 3 links, 31 references. Source: Crossref (member 25296), registered 2020-09-24, last deposited 2026-09-28.

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System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1

Each element by the standard's name and the Handbook's (in grey), read off the record.

The record

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        "value": "Caffeine and Quercetin both are used in combination for the treatment of patient with depression as they are adenosine antagonist due to which they elevate the level of neurotransmitters. The study was designed with two aims. First, is to enhance the solubility and bioavailability of BCS Class II i.e. Quercetin; secondly to ease administration of the formulation to the patient with depression. The culmination of this study, the caffeine and quercetin loaded niosomal in-situ gel for nose-to-brain delivery was formulated. Niosomes were prepared and optimized by using definitive screening design whereas, the Niosomal in-situ gel were prepared and optimized using central composite design. The vesicle size of the optimized batch was found to be 0.281±0.26µm. The % EE of all niosomal batches was found to be in a range of 81.52±0.21% to 98.72±0.16% for Caffeine and 94.3±0.31 to 99.73±0.23 for Quercetin and the cumulative % release was found to be in a range of 72.09±0.18% to 103.3±0.26% for Caffeine and 10.9±0.31% to 37.06±0.15% for Quercetin at 4hrs. DSC, FTIR studies were performed for pure drug and optimized niosomal batch. All the gels as per design were formulated, where the Spreadability was found to be in range of 5.1±0.26cm to 7.9±0.16cm and viscosity after gelation in range of 1800±0.11cps to 4780±0.26cps. The % drug permeated was found to be in range of 85.86±0.015% to 98.61±0.024% for Caffeine and 22.65±0.19% to 33.23±0.34% for Quercetin at 6hrs. These results indicated that niosomal In-situ gel can be used to enhance the bioavailability of drug by directly delivering the drug to the brain by avoiding first pass effect",
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            "unstructured": "Puneet Bagga, Anup N. Chugani, Anant B. Patel (2015). Neuroprotective Effects of Caffeine in MPTP Model of Parkinson’s D isease: A 13CNMR Study.Neurochemistry International 92: 25-34"
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            "doi": "10.1080/10717540701603597",
            "unstructured": "Payam Khazaeli and Abbas Pardakhty (2007). Caffeine-Loaded Niosomes: Characterization and in VitroRelease Studies. Drug Delivery 14: 447–452"
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            "unstructured": "Higgins GA, Grzelak ME, Pond AJ, et al (2007). The effect of caffeine to increase reaction time in the rat dur ing a test of attention is mediated through antagonism of adenosine A (2A) receptors. Behavioural Brain Research 185: 32-42. [6]N D Volkow, G-J Wang, J Logan, D Alexoff, J S Fowler, P K Thanos, C Wong, V Casado, S Ferre, D Tomasi (2015). Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain. Transl Psychiatry 5: e549"
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            "doi": "10.1021/jm970446z",
            "unstructured": "Moro S, van Rhee AM, Sanders LH, et al (1998). Flavonoid derivatives as adenosine receptor antagonists: a comparison of t he hypothetical receptor binding site based on a comparative molecular field analysis model. Journal of Medicinal Chemistry 41: 46-52"
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            "unstructured": "Zaynab Sadeghi Ghadi, Rassoul Dinarvand, Neda Asemi, Fereshteh Talebpour Amiri, Pedram Ebrahimnejad (2019). Preparation, characterization and in vivo evaluation of novel hyaluronan containing niosomes tailored by Box-Behnken design to co-encapsulate curcumin and quercetin. European Journal of Pharmaceutical Sciences 130: 234-246"
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            "unstructured": "Lohumi Ashutosh, Rawat Suman, Sarkar Sidhyartha, Sipai Altaf bhai, Yadav M. Vandana (2012). A Novel Drug Delivery System: Niosomes Review. Journal of Drug Delivery & Therapeutics 2:129-135"
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            "unstructured": "M. Parvathi (2012). Intranasal Drug Delivery to Brain: An Overview. International Journal of Research in Pharmacy and Chemistry 2: 889- 895"
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            "unstructured": "Kartik d. Pandya, snehal S. Patel, Avinash k. Seth, Chainesh N. Shah, Chintan J. Aundhia, Nirmal V. Shah, Vinod D. Raman i, Ankur Javia (2016). Niosome: An unique drug delivery system. An international journal of pharmaceutical sciences 7: 85-99. [13]Didem Ag Seleci, Muharrem Seleci, Johanna-Gabriela Walter, Frank Stahl, Thomas Scheper (2016). Niosomes as Nanoparticular Drug Carriers: Fundamentals and Recent Applications. Journal of Nanomaterials : 1-13"
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            "unstructured": "Tinku Singhal, Mohd. Mujeeb, Abdul Ahad, Mohd. Aqil, Syed Obaidur Rahman, Abul Kalam Najmi, Waseem Ahmad Siddiqui (2019). Preparation, optimization and biological evaluation of gymnemic acid loaded niosomes against streptozotocin-nicotinamide induced diabetic nephropathy in Wistar Rats. Journal of Drug Delivery Science and Technolog y54: 1-40"
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            "doi": "10.1016/j.apsb.2011.09.002",
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            "unstructured": "Dyandevi Mathure, Jyotsana R Madan, Kishore N. Gujar, Ashok Tu psamundre, Hemant A. Ranpise and Kamal Dua (2018). Formulation and Evaluation of Niosomal in situ Nasal Gel of a Serotonin Receptor Agonist, Buspirone Hydrochloride for the Brain Delivery via Intranasal Route. Pharmaceutical Nanotechnology 6: 69-78"
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            "unstructured": "Deepa T Vasudevan, S Gopalakrishnan, Kavitha R Dinesh, KG Ravikumar, KR Sundaram, AKK Unni (2011). Formulation and in-vitro evaluation of chrysophanol topical gel. Asian Journal of Pharmaceutics 5: 120-124"
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The Kernel Metadata Declaration

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