Kernel Metadata Declaration — on demand

What the DOI identifies

Formulation, Development and Evaluation of Lopinavir Loaded Polymeric Micelles

10.46243/jst.2020.v5.i4.pp173-187 · JournalArticle — an article in a journal · Digital · Visual · Language · en

Published 2020-07-30

Part of Journal of Science & Technology · ISSN 2456-5660 · no. Volume 5 · pp. 173–187

Principal agents

• Longman Publishers (publisher → Publisher)

Also in the record, outside the Kernel: the abstract, the licence, 3 links, 26 references. Source: Crossref (member 25296), registered 2020-07-30, last deposited 2026-09-17.

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System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1

Each element by the standard's name and the Handbook's (in grey), read off the record.

The record

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    "abstract": {
        "value": "Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as Objective:first to enhance the solubility and bioavailability of the BCS class IV drug and second to avoid the combination of lopinavir rand ritonavir and use single lopinavir to preparation of polymeric micelle also to avoid the disadvantages related to the oral administration. Method:The different pluronic (F188 &F127) and co-solvent (Tween80) were chosen & the micelles were prepared by using different Drug: polymer ratio with or without cosolvent and drug Lopinavir. Formulations were been characterized by critical micelle concentration(CMC) value, micellesize,DSC, XRD, loading efficiency, % drug loading and stability.Result:Mixed micelle (hydrophobic &hydrophilic) obtained from optimized batch shows the highest entrapment of 29%with the pluronic F68 with the use of co-solvent and the vesicle size of 0.156µm the DSC, FTIR, XRD study was also done for lopinavir and optimized formulation .Conclusion: The pluronic F68 with the co-solvent showed fairly high entrapment efficiency, loading capacity than the mixed Pluronic in combination",
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            "key": "ref1",
            "unstructured": "Langer R. Drug delivery and targeting. Nature. 1998; 392(6679): 5–10"
        },
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            "doi": "10.1016/j.addr.2012.09.019",
            "unstructured": "Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.Adv Drug Deliv Rev. 2001; 46: 3-26"
        },
        {
            "key": "ref3",
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        },
        {
            "key": "ref4",
            "doi": "10.2174/138945006777435245",
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        {
            "key": "ref7",
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            "unstructured": "Nakasima K, Bahadur P. Aggregation of water-soluble block copolymers in aqueous solutions: recent trends. Adv. Colloid Interface Sci. 2006; 123: 75"
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        {
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        {
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        {
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        {
            "key": "ref23",
            "doi": "10.1016/j.colsurfa.2010.04.025",
            "unstructured": "Kadam Y, Bharatiya B, Hassan PA, Verma G, Aswal VK, Bahadur P. Effect of an amphiphilic diol (Surfynol®) on the micellar characteristics of PEO–PPO–PEO block copolymers in aqueous solutions. Colloids Surf. A: Physico chem. Eng. Aspects. 2010; 363(1): 110"
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            "doi": "10.1194/jlr.m600211-jlr200",
            "unstructured": "SumbulFatma, ReuvenYakubov, Kamran Anwar M, MahmoodHussain. Pluronic L81 enhances triacylglycerol accumulation in the cytosol and inhibits chylomicron secretion. Journal of Lipid Research. 2006; 47(11): 2422-32"
        },
        {
            "key": "ref26",
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The Kernel Metadata Declaration

DOIMetadataKernel.xsd · namespace http://www.doi.org/2010/DOISchema · Attribute Value Sets 2.3 · draft — the agency's DOI name is filled in on accreditation

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