Kernel Metadata Declaration — on demand
ISO 26324 asks a DOI Registration Agency to produce a Kernel Metadata Declaration for every DOI it issues. Give any DOI: its public record becomes a record in the Smart Scholars DOI Metadata Format 1.0, checked against every rule, and declared as the Kernel XML.
✓ Meets every rule of the format
The record below is complete and every controlled value is a DOI Attribute Value Set 2.3 spelling. The Declaration on the right follows DOIMetadataKernel.xsd element by element.
What the DOI identifies
Lumefantrine Solid Dispersion Formulation Development and Characterization with Piperine for Solubility Enhancement
10.46243/jst.2020.v5.i04.pp223-229 · JournalArticle — an article in a journal · Digital · Visual · Language · en
Published 2020-08-27
Part of Journal of Science & Technology · ISSN 2456-5660 · vol. 05 · no. 04 · pp. 223–229
Principal agents
- Dr.Rafia (author → Author)
- Dr.Ratnasree (author → Author)
- Nethikoppula Pravallika (author → Author)
- Longman Publishers (publisher → Publisher)
Also in the record, outside the Kernel: the abstract, the licence, 4 links, 10 references. Source: Crossref (member 25296), registered 2026-09-10, last deposited 2026-09-20.
System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1
Each element by the standard's name and the Handbook's (in grey), read off the record.
| DOI Name DOI name | 10.46243/jst.2020.v5.i04.pp223-229 |
| Referent Type referentType | Creation |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal |
| Referent Name(s) referentName(s) | Lumefantrine Solid Dispersion Formulation Development and Characterization with Piperine for Solubility Enhancement (PrincipalTitle, en) |
| Basic Metadata basicMetadata | author: Dr.Rafia author: Dr.Ratnasree author: Nethikoppula Pravallika publisher: Longman Publishers published: 2020-08-27 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 05 · no. 04 · pp. 223–229 language: en form: Digital · Visual · Language |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy |
| Created Date issueDate | 2026-09-10 |
| relatedIdentifiers | none needed — the descriptive metadata is in this record |
The record
{
"format": "smartscholars-doi-metadata/1.0",
"doi": "10.46243/jst.2020.v5.i04.pp223-229",
"referent": "Creation",
"type": "JournalArticle",
"structural_type": "Digital",
"modes": [
"Visual"
],
"characters": [
"Language"
],
"titles": [
{
"value": "Lumefantrine Solid Dispersion Formulation Development and Characterization with Piperine for Solubility Enhancement",
"type": "PrincipalTitle",
"lang": "en"
}
],
"identifiers": [
{
"type": "DOI",
"value": "10.46243/jst.2020.v5.i04.pp223-229"
}
],
"agents": [
{
"role": "author",
"name": {
"given": "",
"family": "Dr.Rafia"
},
"sequence": "first"
},
{
"role": "author",
"name": {
"given": "",
"family": "Dr.Ratnasree"
},
"sequence": "additional"
},
{
"role": "author",
"name": {
"given": "Nethikoppula",
"family": "Pravallika"
},
"sequence": "additional"
},
{
"role": "publisher",
"name": {
"org": "Longman Publishers"
}
}
],
"dates": {
"published": "2020-08-27",
"date_type": "PublicationDate",
"online": "2020-08-27"
},
"language": "en",
"container": {
"type": "Journal",
"titles": [
{
"value": "Journal of Science & Technology",
"type": "PrincipalTitle"
}
],
"identifiers": [
{
"type": "ISSN",
"value": "2456-5660",
"medium": "electronic"
}
],
"volume": "05",
"issue": "04",
"pages": {
"first": "223",
"last": "229"
}
},
"links": [
{
"url": "https://www.jst.org.in/index.php/pub/article/view/666",
"return_type": "text/html",
"primary": true
},
{
"url": "https://www.jst.org.in/index.php/pub/article/download/666/594",
"purpose": "text-mining",
"return_type": "application/pdf"
},
{
"url": "https://www.jst.org.in/index.php/pub/article/download/666/3191",
"purpose": "text-mining",
"return_type": "application/xml"
},
{
"url": "https://www.jst.org.in/index.php/pub/article/view/666/594",
"purpose": "similarity-checking"
}
],
"abstract": {
"value": "Lumefantrine's limited water solubility and variable bioavailability are linked to its crystallinity and efflux mediated by P-glycoprotein (P-gp). Here, amorphous solid dispersions (SD) of lumefantrine (LUMF) including piperine (PIP), a P-gp and CYP3A4 inhibitor, were produced using Copovidone/Kollidon® VA 64 (KOL) at three different ratios with increasing polymer content in order to increase the dissolution and, therefore, the oral bioavailability. Using DSC, FTIR, and XRD, the PIP-LUMF-KOL SD at a ratio of 1:6:18 showed increased aqueous solubility of LUMF. While FTIR tests looked into potential intermolecular interactions between LUMF and PIP and/or KOL, the DSC thermogram and XRD diffractogram of LUMF-PIP-SD validated the enhanced dissolving brought on by LUMF's loss of crystallinity. The stability of LUMFPIP-Sol SD under stressful temperature and humidity conditions for 90 days was confirmed by DSC and dissolving studies. Overall, the findings point to the possibility that increasing the SD of LUMF combined with P-gp inhibitor PIP may improve solubility and, in turn, increase LUMF's bioavailability.",
"lang": "en"
},
"license": {
"url": "https://creativecommons.org/licenses/by/4.0",
"start": "2020-08-27",
"applies_to": "vor"
},
"references": [
{
"key": "ref1",
"doi": "10.1016/j.ejpb.2015.10.001",
"unstructured": "Du Plessis LH, Govender K, Denti P, Wiesner L. In vivo efficacy and bioavailability of lumefantrine : Evaluating the application of Pheroid technology. Eur J Pharm Biopharm. 2015; 97:68-77"
},
{
"key": "ref2",
"doi": "10.1186/2008-2231-21-27",
"unstructured": "Patel K, Sarma V, Vavia P. Design and evaluation of lumefantrine–oleic acid self-nanoemulsifying ionic complex for enhanced dissolution. DARU J Pharm Sci. 2013; 21(1):1-11"
},
{
"key": "ref3",
"doi": "10.2165/00003088-199937020-00002",
"unstructured": "White NJ, vanVugt M, Ezzet FD. Clinical pharmacokinetics and pharmacody namics of ar temether-lumefant rine. Clin Pharmacokinet. 1999; 37(2):105-125"
},
{
"key": "ref4",
"doi": "10.1128/aac.01382-13",
"unstructured": "Wahajuddin M, Raju KS, Singh SP, Taneja I. Investigation of the functional role of P-glycoprotein in limiting the oral bioavailability of lumefantrine. Antimicrob Agents Chemother. 2014; 58(1):489- 494"
},
{
"key": "ref5",
"doi": "10.1016/j.colsurfb.2012.01.047",
"unstructured": "Gahoi S, Jain GK, Tripathi R, Pandey SK, Anwar M, Warsi MH, Singhal M, Khar RK, Ahmad, FJ. Enhanced antimalarial activity of lumefantrine nanopowder prepared by wet-milling DYNO MILL technique. Colloids Surf B Biointerfaces. 2012; 95:16-22. 228 | P ag e"
},
{
"key": "ref6",
"doi": "10.1016/j.ijpharm.2016.10.064",
"unstructured": "Garg A, B halala K, T omar D S. I n-situ s ingle p ass i ntestinal permeability and pharmacokinetic study of developed lumefantrine loaded solid lipid nanoparticles. Int J Pharm. 2017; 516(1-2):120-130"
},
{
"key": "ref7",
"doi": "10.2174/15672018113109990044",
"unstructured": "Bhatnagar P, Dhote V, Mahajan S, Mishra P, Mishra D. Solid dispersion in pharmaceutical drug development: from basics to clinical applications. Curr Drug Deliv. 2014; 11(2):155-171"
},
{
"key": "ref8",
"doi": "10.1016/j.xphs.2015.10.008",
"unstructured": "Baghel S, Cathcart H, O’Reilly NJ. Polymeric Amorphous Solid Dispersions: A Rev iew of amorphizat ion, cr yst allizat ion, stabilizat ion, solid-state characterizat ion, and aqueous solubilization of biopharmaceutical classification system class II drugs. J Pharm Sci. 2016;105(9):2527–2544"
},
{
"key": "ref9",
"doi": "10.1016/j.xphs.2016.08.017",
"unstructured": "Huang S, Mao C, Williams III RO, Yang CY. Solubility advantage (and disadvantage) of pharmaceutical amorphous solid dispersions. J Pharm Sci. 2016; 105(12):3549-3561"
},
{
"key": "ref10",
"doi": "10.1002/jps.23125",
"unstructured": "Sathigari SK, Radhakrishnan VK, Davis VA, Parsons DL, Babu RJ. Amorphous-state characterization of efavirenz—polymer hot-melt extrusion systems for dissolution enhancement. J Pharm Sci. 2012; 101(9):3456–3464"
}
],
"record": {
"registrant": "Longman Publishers",
"registered": "2026-09-10",
"updated": "2026-09-20",
"issue_number": 1,
"source": "crossref-api",
"source_agency": "Crossref (member 25296)"
}
}The Kernel Metadata Declaration
DOIMetadataKernel.xsd · namespace http://www.doi.org/2010/DOISchema · Attribute Value Sets 2.3 · draft — the agency's DOI name is filled in on accreditation
<?xml version="1.0" encoding="UTF-8"?>
<!-- DRAFT declaration: Smart Scholars is not yet a DOI Registration Agency. registrationAgencyDoiName is a marker (10.0/ is no RA's prefix) and is filled in on accreditation. -->
<kernelMetadata xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.doi.org/2010/DOISchema https://www.doi.org/doi_schemas/DOIMetadataKernel.xsd" xmlns="http://www.doi.org/2010/DOISchema">
<referentDoiName>10.46243/jst.2020.v5.i04.pp223-229</referentDoiName>
<primaryReferentType>Creation</primaryReferentType>
<registrationAgencyDoiName>10.0/smart-scholars-draft</registrationAgencyDoiName>
<issueDate>2026-10-04</issueDate>
<issueNumber>1</issueNumber>
<referentCreation>
<name primaryLanguage="en">
<value>Lumefantrine Solid Dispersion Formulation Development and Characterization with Piperine for Solubility Enhancement</value>
<type>PrincipalTitle</type>
</name>
<identifier>
<nonUriValue>10.46243/jst.2020.v5.i04.pp223-229</nonUriValue>
<uri returnType="text/html" doesContentNegotiation="true">https://doi.org/10.46243/jst.2020.v5.i04.pp223-229</uri>
<type>DOI</type>
</identifier>
<identifier>
<uri returnType="text/html">https://www.jst.org.in/index.php/pub/article/view/666</uri>
<type>URI</type>
</identifier>
<identifier>
<uri>https://www.jst.org.in/index.php/pub/article/download/666/594</uri>
<type>URI</type>
</identifier>
<identifier>
<uri returnType="application/xml">https://www.jst.org.in/index.php/pub/article/download/666/3191</uri>
<type>URI</type>
</identifier>
<identifier>
<uri>https://www.jst.org.in/index.php/pub/article/view/666/594</uri>
<type>URI</type>
</identifier>
<structuralType>Digital</structuralType>
<mode>Visual</mode>
<character>Language</character>
<type>JournalArticle</type>
<principalAgent>
<name>
<value>Dr.Rafia</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>Dr.Ratnasree</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>Nethikoppula Pravallika</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>Longman Publishers</value>
<type>PrincipalName</type>
</name>
<role>Publisher</role>
</principalAgent>
<linkedCreation>
<name>
<value>Journal of Science & Technology</value>
<type>PrincipalTitle</type>
</name>
<identifier>
<nonUriValue>2456-5660</nonUriValue>
<type>ISSN</type>
</identifier>
<referentCreationRole>Part</referentCreationRole>
<referentCreationSequenceIdentifier>
<value>05</value>
<type>VolumeNumber</type>
</referentCreationSequenceIdentifier>
<referentCreationSequenceIdentifier>
<value>04</value>
<type>IssueNumber</type>
</referentCreationSequenceIdentifier>
<referentCreationSequenceIdentifier>
<value>223-229</value>
<type>PageNumber</type>
</referentCreationSequenceIdentifier>
</linkedCreation>
<language>en</language>
<languageOfReferentContent>
<language>en</language>
<languageOfReferentContentType>Original</languageOfReferentContentType>
</languageOfReferentContent>
<creationDate>
<date>2020-08-27</date>
<creationDateType>PublicationDate</creationDateType>
</creationDate>
</referentCreation>
</kernelMetadata>
