Kernel Metadata Declaration — on demand
ISO 26324 asks a DOI Registration Agency to produce a Kernel Metadata Declaration for every DOI it issues. Give any DOI: its public record becomes a record in the Smart Scholars DOI Metadata Format 1.0, checked against every rule, and declared as the Kernel XML.
✓ Meets every rule of the format
The record below is complete and every controlled value is a DOI Attribute Value Set 2.3 spelling. The Declaration on the right follows DOIMetadataKernel.xsd element by element.
What the DOI identifies
LC-MS/MS-Based Selective Degradant Separation and Mass Spectral Characterization of Viloxazine
10.46243/jst.2020.v5.i04.pp215-222 · JournalArticle — an article in a journal · Digital · Visual · Language · en
Published 2020-08-27
Part of Journal of Science & Technology · ISSN 2456-5660 · vol. 05 · no. 04 · pp. 215–222
Principal agents
- Shivaprasad (author → Author)
- Adithyamathur (author → Author)
- Dr.Ratnasre (author → Author)
- Longman Publishers (publisher → Publisher)
Also in the record, outside the Kernel: the abstract, the licence, 4 links, 6 references. Source: Crossref (member 25296), registered 2026-09-10, last deposited 2026-09-20.
System metadata — ISO 26324:2025, Annex B · DOI Handbook 10.1
Each element by the standard's name and the Handbook's (in grey), read off the record.
| DOI Name DOI name | 10.46243/jst.2020.v5.i04.pp215-222 |
| Referent Type referentType | Creation |
| Referent Sub-Type referentSubType | JournalArticle — an article in a journal |
| Referent Name(s) referentName(s) | LC-MS/MS-Based Selective Degradant Separation and Mass Spectral Characterization of Viloxazine (PrincipalTitle, en) |
| Basic Metadata basicMetadata | author: Shivaprasad author: Adithyamathur author: Dr.Ratnasre publisher: Longman Publishers published: 2020-08-27 part of: Journal of Science & Technology · ISSN 2456-5660 · vol. 05 · no. 04 · pp. 215–222 language: en form: Digital · Visual · Language |
| Referent Identifier(s) alternateIdentifier(s) | none besides the DOI |
| Registration Authority registrationAuthorityCode | Crossref — issued by Crossref (member 25296); held here as a copy |
| Created Date issueDate | 2026-09-10 |
| relatedIdentifiers | none needed — the descriptive metadata is in this record |
The record
{
"format": "smartscholars-doi-metadata/1.0",
"doi": "10.46243/jst.2020.v5.i04.pp215-222",
"referent": "Creation",
"type": "JournalArticle",
"structural_type": "Digital",
"modes": [
"Visual"
],
"characters": [
"Language"
],
"titles": [
{
"value": "LC-MS/MS-Based Selective Degradant Separation and Mass Spectral Characterization of Viloxazine",
"type": "PrincipalTitle",
"lang": "en"
}
],
"identifiers": [
{
"type": "DOI",
"value": "10.46243/jst.2020.v5.i04.pp215-222"
}
],
"agents": [
{
"role": "author",
"name": {
"given": "",
"family": "Shivaprasad"
},
"sequence": "first"
},
{
"role": "author",
"name": {
"given": "",
"family": "Adithyamathur"
},
"sequence": "additional"
},
{
"role": "author",
"name": {
"given": "",
"family": "Dr.Ratnasre"
},
"sequence": "additional"
},
{
"role": "publisher",
"name": {
"org": "Longman Publishers"
}
}
],
"dates": {
"published": "2020-08-27",
"date_type": "PublicationDate",
"online": "2020-08-27"
},
"language": "en",
"container": {
"type": "Journal",
"titles": [
{
"value": "Journal of Science & Technology",
"type": "PrincipalTitle"
}
],
"identifiers": [
{
"type": "ISSN",
"value": "2456-5660",
"medium": "electronic"
}
],
"volume": "05",
"issue": "04",
"pages": {
"first": "215",
"last": "222"
}
},
"links": [
{
"url": "https://www.jst.org.in/index.php/pub/article/view/664",
"return_type": "text/html",
"primary": true
},
{
"url": "https://www.jst.org.in/index.php/pub/article/download/664/592",
"purpose": "text-mining",
"return_type": "application/pdf"
},
{
"url": "https://www.jst.org.in/index.php/pub/article/download/664/3194",
"purpose": "text-mining",
"return_type": "application/xml"
},
{
"url": "https://www.jst.org.in/index.php/pub/article/view/664/592",
"purpose": "similarity-checking"
}
],
"abstract": {
"value": "This study presents a unique method for the selective extraction of degradants from API using HPLC and online connection of a SCIEX QTRAP 5500 mass spectrometer with a triple quadrupole mass analyzer and PDA detector. Chromatography was employed using mobile phase ACN: 0.1% TEA (40:60) %v/v to separate all degradants on the Agilent Eclipse XDB (150 mm x 4.6 mm, 3.5 μ) column. It was discovered that the maximum absorption occurs at 220 nm, allowing for simultaneous detection unaffected by the placebo matrix. It was decided to approve the recommended RP-HPLC technique in accordance with the general ICH guidelines. The parameters that were considered adequate were specificity, linearity, LoD, LoQ, accuracy, precision, and robustness of validation. The suggested approach demonstrates excellent linearity and robust correlation over the range of 12.5–75 μg/mL. The precision tests' percent RSD was less than 2%, whilst the accuracy trials yielded consistent recoveries (95–105%). It may be possible to determine the inherent stability of the drug molecules in the present formulation by doing forced degradation tests and evaluating the degradation products generated under different stress conditions. By using MS/MS analyses, the generated degradants were further described and effectively isolated. Validation studies showed that the recently developed method is stable and sensitive to all degradants. Validation studies show that within the required operating range, the newly created approach was also linear, accurate, precise, robust, and selective.",
"lang": "en"
},
"license": {
"url": "https://creativecommons.org/licenses/by/4.0",
"start": "2020-08-27",
"applies_to": "vor"
},
"references": [
{
"key": "ref1",
"doi": "10.1093/ajhp/zxab231",
"unstructured": "Viloxazine hydrochloride. Am J Health Syst Pharm [Internet]. 2021 [cited 2022 Jun 10];78(17):1544–7. Available from: https:// go.drugbank.com/salts/DBSALT001262"
},
{
"key": "ref2",
"unstructured": "PubChem. Viloxazine [Internet]. Nih.gov. [cited 2022 Jun 10]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/ Viloxazine"
},
{
"key": "ref3",
"doi": "10.2147/jep.s256586",
"unstructured": "Yu C, Garcia-Olivares J, Candler S, Schwabe S, Maletic V. New insights into the mechanism of action of viloxazine: serotonin and norepinephrine modulating properties. Journal of Experimental Pharmacology. 2020; 12:285"
},
{
"key": "ref4",
"unstructured": "Drugs.com. [cited 2022 Jun 10]. Available from: https://www.drugs. com/history/qelbree.htmL"
},
{
"key": "ref5",
"unstructured": "Viloxazine oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing-WebMD [Internet]. Webmd.com. [cited 2022 Jun 10]. Available from: https://www.webmd.com/drugs/2/drug-181227/ Viloxazine-oral/details"
},
{
"key": "ref6",
"unstructured": "https://www.ich.org/page/quality-guidelines"
}
],
"record": {
"registrant": "Longman Publishers",
"registered": "2026-09-10",
"updated": "2026-09-20",
"issue_number": 1,
"source": "crossref-api",
"source_agency": "Crossref (member 25296)"
}
}The Kernel Metadata Declaration
DOIMetadataKernel.xsd · namespace http://www.doi.org/2010/DOISchema · Attribute Value Sets 2.3 · draft — the agency's DOI name is filled in on accreditation
<?xml version="1.0" encoding="UTF-8"?>
<!-- DRAFT declaration: Smart Scholars is not yet a DOI Registration Agency. registrationAgencyDoiName is a marker (10.0/ is no RA's prefix) and is filled in on accreditation. -->
<kernelMetadata xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.doi.org/2010/DOISchema https://www.doi.org/doi_schemas/DOIMetadataKernel.xsd" xmlns="http://www.doi.org/2010/DOISchema">
<referentDoiName>10.46243/jst.2020.v5.i04.pp215-222</referentDoiName>
<primaryReferentType>Creation</primaryReferentType>
<registrationAgencyDoiName>10.0/smart-scholars-draft</registrationAgencyDoiName>
<issueDate>2026-10-04</issueDate>
<issueNumber>1</issueNumber>
<referentCreation>
<name primaryLanguage="en">
<value>LC-MS/MS-Based Selective Degradant Separation and Mass Spectral Characterization of Viloxazine</value>
<type>PrincipalTitle</type>
</name>
<identifier>
<nonUriValue>10.46243/jst.2020.v5.i04.pp215-222</nonUriValue>
<uri returnType="text/html" doesContentNegotiation="true">https://doi.org/10.46243/jst.2020.v5.i04.pp215-222</uri>
<type>DOI</type>
</identifier>
<identifier>
<uri returnType="text/html">https://www.jst.org.in/index.php/pub/article/view/664</uri>
<type>URI</type>
</identifier>
<identifier>
<uri>https://www.jst.org.in/index.php/pub/article/download/664/592</uri>
<type>URI</type>
</identifier>
<identifier>
<uri returnType="application/xml">https://www.jst.org.in/index.php/pub/article/download/664/3194</uri>
<type>URI</type>
</identifier>
<identifier>
<uri>https://www.jst.org.in/index.php/pub/article/view/664/592</uri>
<type>URI</type>
</identifier>
<structuralType>Digital</structuralType>
<mode>Visual</mode>
<character>Language</character>
<type>JournalArticle</type>
<principalAgent>
<name>
<value>Shivaprasad</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>Adithyamathur</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>Dr.Ratnasre</value>
<type>PrincipalName</type>
</name>
<role>Author</role>
</principalAgent>
<principalAgent>
<name>
<value>Longman Publishers</value>
<type>PrincipalName</type>
</name>
<role>Publisher</role>
</principalAgent>
<linkedCreation>
<name>
<value>Journal of Science & Technology</value>
<type>PrincipalTitle</type>
</name>
<identifier>
<nonUriValue>2456-5660</nonUriValue>
<type>ISSN</type>
</identifier>
<referentCreationRole>Part</referentCreationRole>
<referentCreationSequenceIdentifier>
<value>05</value>
<type>VolumeNumber</type>
</referentCreationSequenceIdentifier>
<referentCreationSequenceIdentifier>
<value>04</value>
<type>IssueNumber</type>
</referentCreationSequenceIdentifier>
<referentCreationSequenceIdentifier>
<value>215-222</value>
<type>PageNumber</type>
</referentCreationSequenceIdentifier>
</linkedCreation>
<language>en</language>
<languageOfReferentContent>
<language>en</language>
<languageOfReferentContentType>Original</languageOfReferentContentType>
</languageOfReferentContent>
<creationDate>
<date>2020-08-27</date>
<creationDateType>PublicationDate</creationDateType>
</creationDate>
</referentCreation>
</kernelMetadata>
